65507 comments

• Comment Link
  
  hotav.cyou

  Saturday, 27 September 2025 12:54

  best supplement stack 2015
  
  
  https://music.1mm.hk/alisiamatos655 what supplements do pro bodybuilders
  take
  
  
  http://energonspeeches.com/@brentrossetti?page=about first Steroid cycle before and after
  
  
  https://music.1mm.hk/alisiamatos655 is short term prednisone use
  dangerous
  
  
  https://cloveebiz.com.ng/@claude09035029?page=about anavar steroids
  
  
  http://www.huastech.com.cn:81/chantalurban60 anabolic steroid for sale
  
  
  https://git.bloade.com/alena68r332849 best steroid cycle for bulking
  
  
  https://gitlab.oc3.ru/u/bianca56890166 lean steroid cycle
  
  
  https://git.getmind.cn/dexterhinkle48 ibuysteroids
  
  
  https://ionvideo.org/@jakemerritt94?page=about best ripping supplements
  
  
  https://thescouter.co.uk/@braydenlorimer?page=about steroid Free
  bodybuilding
  
  
  https://www.nenboy.com:29283/francine329134 how to get anavar prescription
  
  
  https://git.lmskaran.com/derekheady8261 where can i buy illegal steroids
  
  
  https://gitea.ashcloud.com/linneadurkin45 how to Get big without supplements
  
  
  https://gitea.joodit.com/mariannesteffa which of the following Statements
  about anabolic steroids Is false?
  
  
  https://git.hexaquo.at/ashleywitzel2 pharmaceutical grade steroids For
  sale
  
  
  https://skiivie.com/@anneslavin1978?page=about how much steroids cost
  
  
  https://gitea.pnkx.top:8/angelinamcshar valley
  
  
  https://git.limework.net/almafriend695 purchase legal steroids
• Comment Link
  
  gitimpo.liara.run

  Saturday, 27 September 2025 12:53

  gnc appetite suppressant energy booster
• Comment Link
  
  valley.Md

  Saturday, 27 September 2025 12:50

  sideaffects of steriods
• Comment Link
  
  git.suika.org

  Saturday, 27 September 2025 12:50

  anabolic steroid law
  
  
  https://git.srblerp.com/ethanhacker93 what are anabolic steroids side effects
  
  
  https://platform.giftedsoulsent.com/floydvale1077 ordering steroids
  online safe
  
  
  https://viraltubex.com/@april759071419?page=about which is true regarding anabolic steroids and supplements?
  
  
  
  https://sounddeep.blacktube.in/hannamcduffie5 is it possible to get big without steroids
  
  
  https://loveis.app/@carmelxiy75707 valley
  
  
  https://kayesbamusic.com/keisha57203375 Who Invented Steroids
  
  
  https://pilowtalks.com/@juliogrissom90 valley
  
  
  https://homeablazebyhispresence.dennmachinery.com/@calebclegg279?page=about taking creatine while on testosterone
  
  
  https://homeablazebyhispresence.dennmachinery.com/@calebclegg279?page=about valley
  
  
  https://ceedmusic.com/elizabeth34j30 best legal steroid
  stack
  
  
  https://date.ainfinity.com.br/@karinegreenwoo I roids
  
  
  https://www.nenboy.com:29283/francine329134 World Abs Pro Stack Review
  
  
  https://playtube.live//@colleen8107940?page=about valley
  
  
  https://rapid.tube/@danellechristy?page=about best steroid to
  lose belly fat
  
  
  https://lawrencewilbert.com/read-blog/20676_anavar-solely-6-weeks-75-mg-ed-results-with-footage.html does dbol give you energy
  
  
  https://grafana.jasonstolle.com/angelastrain71 Why do people
  do steroids
  
  
  http://git.yinas.cn/jaydouglass43 Arnold steroid cycle
  
  
  https://git.andy.lgbt/amelieburbank anabolic steroids and alcohol
• Comment Link
  
  Https://git.camus.cat

  Saturday, 27 September 2025 12:45

  best steroid to burn fat
• Comment Link
  
  Https://lesla.com/@Lorettatoll456

  Saturday, 27 September 2025 12:43

  is it possible to get big without steroids
  
  
  https://weshareinterest.com/@floreneelzy673 seriods
  
  
  http://gitea.ucarmesin.de/eybfelix23584 Valley
  
  
  https://www.adultgg.com/@augustusdrenna?page=about valley
  
  
  https://gitea.belanjaparts.com/kelvincimitier different anabolic steroids
  
  
  https://git.obo.cash/georgiannatoll anabol 5 Side
  Effects
  
  
  https://mardplay.com/caroleaww8181 best muscle gaining supplements 2015
  
  
  https://git.crudelis.kr/cecilelincoln valley
  
  
  http://newslabx.csie.ntu.edu.tw:3000/hellenorton324 steroids
  short term effects
  
  
  http://git.yinas.cn/jaydouglass43 anabolic.com
  
  
  https://gitea.gm56.ru/ersavis7558178 which of the following is a correct description of an anabolic pathway?
  
  
  
  
  https://cygvideos.com/@jettamidgett33?page=about Most Popular Steroid
  
  
  http://yin520.cn:3000/bebelwb7502316 valley
  
  
  https://wiibiplay.fun/@hassiebrazil0?page=about Valley
  
  
  https://mayotube.co/@erickatrb51295?page=about long term effects of
  performance enhancing drugs
  
  
  https://sound.descreated.com/bettetrost9215 legal steroids australia sale
  
  
  https://igoseeads.com/@clydetracy9158?page=about dianabol and winstrol
  
  
  https://bhojiwoods.com/@rfvahmad551174?page=about anabolic man
  
  
  https://cloveebiz.com.ng/@claude09035029?page=about Valley
• Comment Link
  
  dianabol methandrostenolone cycle

  Saturday, 27 September 2025 12:41

  Anabolic Steroids: Uses, Side Effects, And Alternatives
  
  # Estrogen Receptor‑Positive Breast Cancer: A Comprehensive Overview
  
  Breast cancer remains the most common malignancy among women worldwide.
  Roughly **70 % of all breast cancers** express estrogen receptors (ER), making
  them **estrogen‑receptor‑positive (ER+)** or hormone‑dependent
  tumors. These tumours rely on the growth‑promoting actions of estrogens
  and are therefore uniquely susceptible to therapies that alter estrogen signalling.
  
  
  
  Below is a self‑contained review covering:
  
  1. How ER+ breast cancers develop
  2. The key cellular pathways that drive tumour growth
  3. The spectrum of approved therapeutic agents (and
  their mechanisms)
  4. Emerging treatments that may reshape the future of hormone therapy
  
  ---
  
  ## 1. Pathogenesis: From normal breast epithelium to ER‑positive cancer
  
  | Step | What Happens | Key Mutations / Alterations |
  |------|--------------|-----------------------------|
  | **Normal** | Breast ductal cells express estrogen receptor α (ERα) and proliferate in response to circulating estrogens.
  | — |
  | **Initiation** | DNA damage from oxidative stress, hormonal cycles, or
  carcinogens creates mutations in genes that
  regulate cell cycle and apoptosis. | • **TP53** loss → impaired DNA
  repair
  • **PIK3CA** activating mutations → PI3K/AKT pathway activation
  • **PTEN** loss → AKT hyperactivation |
  | **Promotion** | Aberrant ER signaling, often due to increased estrogen exposure
  (e.g., early menarche, late menopause) or aromatase
  overexpression in adipose tissue. | • Upregulation of **ESR1**
  • Increased local estrogen via **CYP19A1** (aromatase) |
  | **Progression** | Acquisition of additional oncogenic
  mutations, chromosomal instability, and evasion of apoptosis.
  | • **TP53** loss or mutation → genomic instability
  
  • Overexpression of anti‑apoptotic genes (**BCL2**, **MCL1**)
  • Activation of growth factor pathways (EGFR, HER2) |
  | **Metastasis** | Tumor cells disseminate through lymphatics and bloodstream;
  colonize lymph nodes, liver, bone. | • Upregulation of matrix‑degrading enzymes (**MMPs**, **ADAMTS**)
  • Altered adhesion molecules (downregulation of E‑cadherin) |
  
  ---
  
  ## 2. Key Molecular Pathways in Breast Cancer Progression
  
  | Pathway | Biological Function | Clinical Relevance | Potential Therapeutic Targets |
  |---------|---------------------|--------------------|------------------------------|
  | **ER/PR Signaling** | Estrogen- and progesterone-mediated transcription; cell proliferation, survival | Hormone‑responsive tumors (≈70% of breast cancers) | Aromatase inhibitors,
  selective estrogen receptor modulators (SERMs), ER degraders |
  | **HER2/EGFR Family** | Receptor tyrosine kinase signaling
  → MAPK, PI3K/Akt pathways | HER2‑positive (~15–20%) | Trastuzumab,
  pertuzumab, lapatinib, neratinib |
  | **PI3K/Akt/mTOR Pathway** | Cell growth, metabolism, survival; frequently mutated in breast cancer | PIK3CA mutations (~30%); PTEN loss | Alpelisib (PI3Kα
  inhibitor), everolimus (mTOR inhibitor) |
  | **Ras/Raf/MEK/ERK Pathway** | Proliferation signaling cascade | KRAS/BRAF mutations rare in breast but
  targetable downstream | Trametinib, dabrafenib |
  | **DNA Damage Response & Homologous Recombination** | BRCA1/2 defects; synthetic lethality with PARP inhibitors | BRCA-mutated or HRD tumors | Olaparib, talazoparib |
  
  ---
  
  ## 4. Translating Pathway Knowledge into Drug Discovery
  
  ### 4.1 Target Identification and Validation
  - **Computational Filtering**: Combine pathway maps with omics data (RNA‑seq, proteomics) to shortlist
  genes/proteins that are overexpressed or mutated.
  
  - **CRISPR/Cas9 Screens**: Systematically knock out genes
  in breast cancer cell lines to confirm essentiality for proliferation/survival.
  
  
  - **Biomarker Correlation**: Ensure that the target’s activity correlates with
  clinical outcomes (e.g., poor prognosis, resistance).
  
  
  ### 4.2 Hit Discovery Strategies
  | Strategy | Rationale |
  |---|---|
  | **Fragment‑based Screening** | Identify small
  chemical fragments binding to active sites; later merged into potent molecules.
  |
  | **High‑Throughput Virtual Screening** | Use docking against the crystal structure
  of target (e.g., EGFR kinase domain) to prioritize compounds.
  |
  | **Repurposing FDA‑Approved Drugs** | Screen libraries for off‑target activity on the new target; reduces time
  to clinical use. |
  | **Phenotypic Assays in Cancer Cell Lines** | Detect functional inhibitors regardless of binding mode; may uncover novel mechanisms.
  
  |
  
  - Example: Screening kinase inhibitor library against mutant EGFR shows compounds
  with nanomolar potency.
  
  ---
  
  ## 3. From Lead to Pre‑clinical Candidate
  
  | Step | Goal | Typical Activities |
  |------|------|--------------------|
  | **Chemical Optimization** | Improve potency, selectivity, metabolic stability, and reduce toxicity | SAR studies,
  medicinal chemistry iterations, predictive ADME models
  |
  | **In vitro ADMET Profiling** | Evaluate absorption (Caco‑2),
  metabolism (HepG2 microsomes), plasma protein binding
  | LC–MS/MS assays, in silico predictions |
  | **Pharmacokinetic Studies** | Determine half‑life, clearance,
  volume of distribution | Rodent PK studies with IV and PO dosing |
  | **In vivo Efficacy Models** | Confirm target engagement in disease models (e.g.,
  tumor xenografts) | Tumor growth inhibition assays |
  | **Toxicology Studies** | Acute and sub‑chronic toxicity in two
  species | Clinical pathology, histopathology |
  
  ---
  
  ## 3. Detailed Work‑Plan
  
  | Week(s) | Activity & Deliverables | Responsible Person |
  |---------|------------------------|--------------------|
  | 1–2 | • Literature review on target biology and previous inhibitors.
  
  • Selection of lead scaffolds (structure‑activity relationships).
  
  • Draft proposal for synthesis plan. | Lead Chemist |
  | 3–4 | • Design of synthetic route for selected scaffold.
  
  • Procurement of reagents, kits, and instrumentation. | Synthetic Lead |
  | 5–8 | **Synthesis Phase**:
  - Step‑wise assembly of core structure (e.g., building block A).
  
  - Functionalization at positions B & C via SN2 or Suzuki coupling.
  
  - Purification by flash chromatography. | Synthesis Team |
  | 9–10 | **Analytical Characterisation**:
  - NMR (^1H, ^13C) to confirm structure.
  - LC‑MS for mass confirmation.
  - HRMS for exact mass.
  - UV‑Vis & IR as supplementary data.
  Compile full dataset. | Analytical Lead |
  | 11–12 | **Quality Control**:
  - Determine purity by HPLC (≥95%).
  - Check solubility in DMSO and buffer.
  - Store samples at −20 °C, protected from light. | QC Officer |
  | 13 | **Documentation & Reporting**:
  - Prepare final report summarising synthesis, characterization data, purity assessment.
  
  - Upload to central repository; ensure all metadata (batch number, date,
  operator) are recorded. | Project Manager |
  
  ---
  
  ## 4. Contingency Planning
  
  ### 4.1 Failure Modes and Mitigations
  
  | Potential Failure | Root Cause | Immediate Action | Long‑Term Fix |
  |-------------------|------------|------------------|---------------|
  | Low yield (5 % by HPLC) | Side reactions (hydrolysis, racemization) | Adjust purification protocol, add ion exchange steps | Modify protecting groups, employ chiral chromatography if needed |
  | Unexpected mass shift in MS | Incorrect formula or adduct formation | Re‑analyze with higher resolution MS,
  check solvent purity | Verify compound identity via NMR; consider isotopic labeling if necessary |
  | Poor solubility in assay buffer | Inadequate salt form or pH |
  Prepare appropriate salt (e.g., HCl), adjust pH to
  7.0–8.0 | Use co-solvents at ≤1 % DMSO; confirm solubility via visual inspection |
  
  ---
  
  ### 4. Summary
  
  By systematically applying the provided nomenclature rules,
  we can derive a concise SMILES representation for any target compound
  in this series, generate its InChI string, and verify that these identifiers are consistent with each other.
  The final step is to cross‑check these representations against experimental data
  such as HPLC retention times or NMR spectra to ensure the correct stereochemical configuration has been assigned.
  This workflow should enable rapid synthesis, characterization, and validation of all compounds in the series while minimizing errors arising from manual notation.
• Comment Link
  
  https://theindietube.com/

  Saturday, 27 September 2025 12:37

  fast bodybuilding workouts
• Comment Link
  
  dianabol and anavar oral cycle

  Saturday, 27 September 2025 12:35

  Injectable Dianabol 10x50mg Ml Pharma TRT
  
  ## Summary of Amphetamine (Amphetamines)
  
  | Category | Key Points |
  |----------|------------|
  | **What is amphetamine?** | A synthetic stimulant belonging
  to the phenethylamine class. The most common form is *dextroamphetamine* (often sold under brand
  names like Adderall®). |
  | **Mechanism of action** | Increases release and blocks reuptake of dopamine, norepinephrine, and serotonin in the brain. This leads to heightened alertness, energy, and
  focus. |
  | **Medical uses** | • Attention‑Deficit/Hyperactivity Disorder (ADHD)
  • Narcolepsy (sleep disorder)
  • Obesity (in some countries, rarely used) |
  | **Common side effects** | • Insomnia
  • Dry mouth
  • Appetite suppression
  • Increased heart rate and blood pressure
  • Anxiety or irritability |
  | **Potential risks** | • Dependence/abuse potential
  • Cardiovascular strain (especially in those with pre‑existing conditions)
  • Psychiatric effects (agitation, mania, psychosis in susceptible individuals) |
  | **Legal status** | Prescription medication; regulated by
  national health authorities. In many countries, it is classified as
  a controlled substance for non‑medical use. |
  
  ---
  
  ## 4. Practical Recommendations
  
  1. **Avoid Non‑Medical Use of Stimulants**
  - Using prescription stimulants to "boost" focus can be dangerous and counterproductive in the long term.
  
  
  2. **Adopt Healthy Lifestyle Habits**
  - Prioritize sleep, nutrition, hydration, regular physical activity, and stress‑management techniques (e.g., meditation,
  breathing exercises).
  
  3. **Structured Work Sessions**
  - Use evidence‑based time‑management frameworks such as Pomodoro or timeboxing to create
  natural breaks.
  
  4. **Mindful Breaks**
  - During breaks, engage in activities that are restorative: a
  short walk, stretching, listening to music, or simply closing your eyes
  and breathing.
  
  5. **Digital Detox**
  - Reduce screen exposure during breaks; consider using tools like "focus mode" or app blockers
  to limit distracting notifications.
  
  6. **Regular Self‑Assessment**
  - Periodically evaluate how you feel after breaks: are they refreshing?
  Are you still mentally engaged with your work?
  Adjust strategies accordingly.
  
  7. **Professional Guidance**
  - If you suspect underlying fatigue or sleep disorders, consult a healthcare
  professional for personalized advice and possible
  interventions (e.g., CBT‑I for insomnia).
  
  ---
  
  ## Conclusion
  
  Breaks—if chosen wisely—are powerful allies in sustaining high levels of concentration. They provide the brain with the opportunity to
  reset, mitigate cognitive overload, and enhance
  both memory consolidation and creative problem‑solving.
  
  However, ineffective break habits or underlying health issues can diminish their benefits.
  
  
  By understanding the science behind attention, fatigue, and sleep, you
  can craft a personalized break strategy that aligns with your work rhythms.
  Experiment with different durations, activities, and frequencies; monitor
  how each change affects focus and performance.
  Over time, this evidence‑based approach will help you maintain sharper concentration throughout the
  day while preserving overall well‑being.
  
  ---
  
  **Key Takeaways**
  
  - **Attention is a limited resource** that depletes over prolonged
  use.
  - **Micro‑breaks (30 sec–2 min)** and
  longer breaks (5–15 min) both improve focus when timed correctly.
  
  - **Restorative activities** (stretching, walking, breathing,
  or brief naps) are more effective than passive tasks like scrolling social media.
  
  - **Personalization matters**—adjust break duration and activity
  to match individual rhythms and workload demands.
  - **Integrate breaks into your routine** through alarms, apps, or workplace policies for sustainable performance.
• Comment Link
  
  dianabol cycle before and after

  Saturday, 27 September 2025 12:29

  From Mr Average To Superman Health & Wellbeing
  
  From Mr Average … to Superman
  
  
  
  The journey from an ordinary "Mr Average" lifestyle to the pinnacle of physical and mental well‑being is not a sudden leap
  but a series of deliberate steps. It begins with self‑awareness: recognizing that current habits—whether they involve irregular sleep, poor nutrition, or minimal movement—are merely placeholders
  rather than endpoints. The first actionable shift is establishing consistent routines:
  setting fixed wake‑up times, planning balanced meals rich in whole foods, and scheduling regular exercise sessions.
  
  
  
  
  A key pillar of this transformation is nutrition. Transitioning
  from processed, calorie‑dense foods to nutrient‑dense choices such as
  vegetables, lean proteins, healthy fats, and complex carbohydrates fuels the body’s repair mechanisms and supports sustained energy levels.
  Pairing these dietary changes with mindful eating practices—slowly chewing, paying attention to satiety cues, and avoiding distractions—helps prevent overeating.
  
  
  
  
  Physical activity evolves from sporadic workouts into integrated movement habits.
  This could involve a mix of strength training, cardiovascular
  sessions, and flexibility work, tailored to individual goals and capacities.
  Consistency is achieved by setting realistic targets, tracking progress,
  and incorporating variety to maintain motivation.
  
  
  
  Sleep hygiene emerges as another pillar: establishing
  regular sleep schedules, creating restful environments, and minimizing stimulants before bedtime enhances recovery
  and cognitive function.
  
  
  
  Mental resilience is cultivated through stress
  management techniques such as meditation, deep breathing,
  or journaling. Engaging in hobbies, fostering social connections,
  and practicing gratitude can offset the mental demands
  of a busy schedule.
  
  
  
  Collectively, these practices foster a holistic health trajectory: balanced nutrition fuels daily tasks; structured movement prevents deconditioning; adequate rest supports cognitive sharpness; emotional regulation reduces burnout risk; and continuous self-reflection ensures
  alignment with personal values. Over time, this integrated approach builds resilience against chronic disease, enhances productivity,
  and nurtures overall well-being.
  
  
  
  Answer 2
  
  
  
  > The best way to get a clear picture of what’s going on inside the system
  is by looking at the data that comes out from it – the "outputs".
  In a control‑system context you’ll often see that
  an engineer will collect measurements from sensors, feed them
  into a computer, and then use the resulting time series to figure out what the underlying plant
  (the thing being controlled) looks like.
  
  
  
  >
  > One very common approach is called system identification: you design a set of
  experiments (e.g., step or pulse inputs),
  record how the output responds, and then fit a mathematical model – for example an ARX, state‑space, or transfer‑function representation – that
  reproduces that response as closely as possible. Once you have that
  model you can infer internal parameters such as natural
  frequencies, damping ratios, time constants, or even hidden states.
  
  
  
  
  We need to find overlaps between these two texts (the assistant answer
  and the reference answer). We should identify phrases that appear in both texts exactly or
  nearly exactly, including maybe synonyms but likely identical wording.
  
  
  
  
  Let's examine each paragraph of the assistant answer
  for potential overlap with the reference answer.
  
  
  
  
  
  "If you model the system as a block diagram then the only thing that is really changing when you add an integrator is the transfer function that sits between the summing junction and the plant."
  
  
  
  Does any phrase from reference appear? The reference says "When you talk about 'the' or 'a' ...".
  Not relevant. "If you keep the rest of the loop unchanged then the overall open‑loop transfer function just gets an extra factor \(s^-1\)."
  Nothing in common.
  
  
  
  "With a unity‑feedback structure the closed‑loop characteristic equation is"
  
  
  
  Not overlapping.
  
  
  
  "So, from a purely mathematical point of view, adding one pole at the origin moves each zero of the denominator one step to the right on the real axis and introduces a new integrator in the loop."
  
  
  
  No overlap.
  
  
  
  "In practice you rarely want an uncompensated integrator sitting next to another integrator that is already in your plant model." No
  overlap.
  
  
  
  "If you have a plant \(G(s)\) with an integrator, i.e. a pole at the origin, and you simply tack on a PI controller"
  
  
  
  No overlap.
  
  
  
  "This is the classic 'two‑pole integrator' situation that causes the step response to be sluggish and the phase margin to collapse." No overlap.
  
  
  
  
  
  "To get back good performance you usually add a zero close to the plant pole, e.g. in a PI controller or a lead compensator."
  
  
  
  No overlap.
  
  
  
  "The zero cancels one integrator (in the sense of improving the low‑frequency slope) and gives you positive phase boost at the crossover frequency." No overlap.
  
  
  
  
  
  "Another approach is to keep the integral action but to tame it with a lag network that limits the high‑frequency gain, so you still get 0 dB at low frequencies but the phase margin recovers."
  
  
  
  No overlap.
  
  
  
  "In short, yes, you can have a Bode magnitude plot that goes from −20 dB/dec to 0 dB and remains flat after that. You do it by adding a pole (or a pair of poles) in the appropriate location so that the slope change happens at the desired frequency." No overlap.
  
  
  
  
  Thus indeed no overlapping phrase. So we assign probability maybe 0.05
  for match, 0.95 for no-match.
  
  But we must produce "match": either null if no matching phrase or some phrase
  string. If we think it's very unlikely there is a match, we set "match" to null.
  
  
  
  
  
  Ok. Let's output:
  
  
  
  
  "match": null,
  "probabilities": {"Y": 0.05, "N": 0.95}
  
  
  
  
  But also check if the reference answer might have phrase 'you
  can write' or 'you can write a small helper function'.
  The reference answer doesn't include that.
  
  
  
  Thus final.
  "match": null,
  "probabilities": {"Y": 0.05, "N": 0.95}